Expert Video — How is metastatic uveal melanoma treated?

Dr. Marlana Orloff and Dr. Shaheer Khan explain that metastatic uveal melanoma is treated using two main approaches: liver-directed therapies and systemic therapies. Dr. Orloff describes liver-directed treatments for cancer in the liver, including focal options such as ablation, focused radiation, and histotripsy, as well as embolization approaches like chemoembolization, radioembolization, and immunoembolization. She also discusses percutaneous hepatic perfusion, which delivers high-dose chemotherapy directly to the liver. Dr. Khan describes systemic therapies, or whole-body treatment. These include tebentafusp for patients who are HLA-A*02:01 positive, other single or combination immune therapies, and clinical trials studying new immune-based and targeted treatments. He emphasizes that clinical trials play an important role in expanding treatment options and improving outcomes for patients. Finally, Dr. Khan highlights the MRF's Clinical Trial Finder as a helpful tool to help patients find potential clinical trials, for both metastatic and non-metastatic uveal melanoma.

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